tRNA (34-2'-O)-methyltransferase regulator WDR6 (WDR6)
Homo sapiens — UniProt Q9NNW5
Data last refreshed: (UniProt release unknown)
Key facts
tRNA (34-2'-O)-methyltransferase regulator WDR6 (WDR6) is a protein from Homo sapiens identified by UniProt accession Q9NNW5, 1121 residues long. MolForge cross-references it against 0 known binders and 116 disease associations.
- UniProt accession: Q9NNW5; gene symbol WDR6.
- Organism: Homo sapiens.
- Length: 1121 amino acids.
- Top disease associations (Open Targets): body height, lean body mass and sitting height measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | tRNA (34-2'-O)-methyltransferase regulator WDR6 |
|---|---|
| UniProt accession | Q9NNW5 |
| Gene | WDR6 |
| Organism | Homo sapiens |
| Length | 1121 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (116)
Diseases linked to this target (Open Targets).
- body height · score 0.47
- lean body mass · score 0.42
- sitting height measurement · score 0.33
- IGF-1 measurement · score 0.28
- Short stature · score 0.26
- forced expiratory volume · score 0.20
- body weights and measures · score 0.19
- vital capacity · score 0.18
- reticulocyte measurement · score 0.16
- anthropometric measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NNW5-F1 | alphafold | PREDICTED | 85.33 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NNW5.
Amino-acid sequence (1121 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with WDR6?
The strongest Open Targets associations for WDR6 are body height, lean body mass, sitting height measurement, IGF-1 measurement and Short stature.
How long is the WDR6 protein?
The Homo sapiens WDR6 protein (UniProt Q9NNW5) is 1121 amino acids long.
Browse: Targets: W · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NNW5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NNW5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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