Tuftelin (TUFT1)
Homo sapiens — UniProt Q9NNX1
Data last refreshed: (UniProt release unknown)
Key facts
Tuftelin (TUFT1) is a protein from Homo sapiens identified by UniProt accession Q9NNX1, 390 residues long. MolForge cross-references it against 0 known binders and 142 disease associations.
- UniProt accession: Q9NNX1; gene symbol TUFT1.
- Organism: Homo sapiens.
- Length: 390 amino acids.
- Top disease associations (Open Targets): woolly hair-skin fragility syndrome, genetic disorder and ectodermal dysplasia syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tuftelin |
|---|---|
| UniProt accession | Q9NNX1 |
| Gene | TUFT1 |
| Organism | Homo sapiens |
| Length | 390 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (142)
Diseases linked to this target (Open Targets).
- woolly hair-skin fragility syndrome · score 0.51
- genetic disorder · score 0.19
- ectodermal dysplasia syndrome · score 0.18
- hepatocellular carcinoma · score 0.10
- triple-negative breast cancer · score 0.10
- gonorrhea · score 0.08
- serum gamma-glutamyl transferase measurement · score 0.08
- pulmonary fibrosis · score 0.08
- renal cell carcinoma · score 0.07
- Darier disease · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NNX1-F1 | alphafold | PREDICTED | 75.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NNX1.
Amino-acid sequence (390 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TUFT1?
The strongest Open Targets associations for TUFT1 are woolly hair-skin fragility syndrome, genetic disorder, ectodermal dysplasia syndrome, hepatocellular carcinoma and triple-negative breast cancer.
How long is the TUFT1 protein?
The Homo sapiens TUFT1 protein (UniProt Q9NNX1) is 390 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NNX1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NNX1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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