3',5'-cyclic-AMP phosphodiesterase 7B (PDE7B)
Homo sapiens — UniProt Q9NP56
Data last refreshed: (UniProt release unknown)
Key facts
3',5'-cyclic-AMP phosphodiesterase 7B (PDE7B) is a protein from Homo sapiens identified by UniProt accession Q9NP56, 450 residues long. MolForge cross-references it against 2 known binders and 172 disease associations.
- UniProt accession: Q9NP56; gene symbol PDE7B.
- Organism: Homo sapiens.
- Length: 450 amino acids.
- Approved drugs acting on it (DrugCentral): Dipyridamole.
- Top disease associations (Open Targets): coronary artery disease, stroke and heel bone mineral density.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 3',5'-cyclic-AMP phosphodiesterase 7B |
|---|---|
| UniProt accession | Q9NP56 |
| Gene | PDE7B |
| Organism | Homo sapiens |
| Length | 450 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (172)
Diseases linked to this target (Open Targets).
- coronary artery disease · score 0.55
- stroke · score 0.55
- heel bone mineral density · score 0.52
- diabetes mellitus · score 0.50
- Hepatitis, Alcoholic · score 0.48
- body height · score 0.48
- diabetic nephropathy · score 0.47
- chronic kidney disease · score 0.47
- Myocardial Ischemia · score 0.47
- urethritis · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NP56-F1 | alphafold | PREDICTED | 79.34 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NP56.
Amino-acid sequence (450 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target PDE7B?
DrugCentral lists 1 approved drug whose mechanism of action is PDE7B: Dipyridamole.
Which diseases are associated with PDE7B?
The strongest Open Targets associations for PDE7B are coronary artery disease, stroke, heel bone mineral density, diabetes mellitus and Hepatitis, Alcoholic.
How long is the PDE7B protein?
The Homo sapiens PDE7B protein (UniProt Q9NP56) is 450 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NP56 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NP56 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.