Sperm-associated antigen 4 protein (SPAG4)

About Sperm-associated antigen 4 protein

Sperm-associated antigen 4 protein (SPAG4) is a protein from Homo sapiens identified by UniProt accession Q9NPE6, 437 residues long. MolForge cross-references it against 0 known binders and 172 disease associations.

Target properties

Protein name	Sperm-associated antigen 4 protein
UniProt accession	Q9NPE6
Gene	SPAG4
Organism	Homo sapiens
Length	437 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (172)

Diseases linked to this target (Open Targets).

low density lipoprotein cholesterol measurement · score 0.11
azoospermia · score 0.11
blood protein measurement · score 0.10
male infertility with teratozoospermia due to single gene mutation · score 0.10
Abnormality of refraction · score 0.10
partial chromosome Y deletion · score 0.09
spermatogenic failure 20 · score 0.08
spermatogenic failure 5 · score 0.08
spermatogenic failure 39 · score 0.08
spermatogenic failure 11 · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NPE6-F1	alphafold	PREDICTED	70.93	—

Amino-acid sequence (437 residues)

MRRSSRPGSA SSSRKHTPNF FSENSSMSIT SEDSKGLRSA EPGPGEPEGR RARGPSCGEP ALSAGVPGGT TWAGSSQQKP APRSHNWQTA CGAATVRGGA SEPTGSPVVS EEPLDLLPTL DLRQEMPPPR VFKSFLSLLF QGLSVLLSLA GDVLVSMYRE VCSIRFLFTA VSLLSLFLSA FWLGLLYLVS PLENEPKEML TLSEYHERVR SQGQQLQQLQ AELDKLHKEV STVRAANSER VAKLVFQRLN EDFVRKPDYA LSSVGASIDL QKTSHDYADR NTAYFWNRFS FWNYARPPTV ILEPHVFPGN CWAFEGDQGQ VVIQLPGRVQ LSDITLQHPP PSVEHTGGAN SAPRDFAVFG LQVYDETEVS LGKFTFDVEK SEIQTFHLQN DPPAAFPKVK IQILSNWGHP RFTCLYRVRA HGVRTSEGAE GSAQGPH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards