Sperm-associated antigen 4 protein (SPAG4)
Homo sapiens — UniProt Q9NPE6
Data last refreshed: (UniProt release unknown)
Key facts
Sperm-associated antigen 4 protein (SPAG4) is a protein from Homo sapiens identified by UniProt accession Q9NPE6, 437 residues long. MolForge cross-references it against 0 known binders and 172 disease associations.
- UniProt accession: Q9NPE6; gene symbol SPAG4.
- Organism: Homo sapiens.
- Length: 437 amino acids.
- Top disease associations (Open Targets): low density lipoprotein cholesterol measurement, azoospermia and blood protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sperm-associated antigen 4 protein |
|---|---|
| UniProt accession | Q9NPE6 |
| Gene | SPAG4 |
| Organism | Homo sapiens |
| Length | 437 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (172)
Diseases linked to this target (Open Targets).
- low density lipoprotein cholesterol measurement · score 0.11
- azoospermia · score 0.11
- blood protein measurement · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.10
- Abnormality of refraction · score 0.10
- partial chromosome Y deletion · score 0.09
- spermatogenic failure 20 · score 0.08
- spermatogenic failure 5 · score 0.08
- spermatogenic failure 39 · score 0.08
- spermatogenic failure 11 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NPE6-F1 | alphafold | PREDICTED | 70.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NPE6.
Amino-acid sequence (437 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPAG4?
The strongest Open Targets associations for SPAG4 are low density lipoprotein cholesterol measurement, azoospermia, blood protein measurement, male infertility with teratozoospermia due to single gene mutation and Abnormality of refraction.
How long is the SPAG4 protein?
The Homo sapiens SPAG4 protein (UniProt Q9NPE6) is 437 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NPE6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NPE6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.