Frizzled-3 (FZD3)
Homo sapiens — UniProt Q9NPG1
Data last refreshed: (UniProt release unknown)
Key facts
Frizzled-3 (FZD3) is a protein from Homo sapiens identified by UniProt accession Q9NPG1, 666 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.
- UniProt accession: Q9NPG1; gene symbol FZD3.
- Organism: Homo sapiens.
- Length: 666 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, colorectal cancer and cortical thickness.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Frizzled-3 |
|---|---|
| UniProt accession | Q9NPG1 |
| Gene | FZD3 |
| Organism | Homo sapiens |
| Length | 666 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (64)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- colorectal cancer · score 0.33
- cortical thickness · score 0.28
- Hydrocephalus · score 0.26
- Agenesis of corpus callosum · score 0.26
- multicystic dysplastic kidney · score 0.26
- isolated cerebellar hypoplasia/agenesis · score 0.26
- arthrogryposis multiplex congenita · score 0.26
- endometrial cancer · score 0.23
- cortical surface area measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NPG1-F1 | alphafold | PREDICTED | 75.51 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NPG1.
Amino-acid sequence (666 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FZD3?
The strongest Open Targets associations for FZD3 are neurodegenerative disease, colorectal cancer, cortical thickness, Hydrocephalus and Agenesis of corpus callosum.
How long is the FZD3 protein?
The Homo sapiens FZD3 protein (UniProt Q9NPG1) is 666 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NPG1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NPG1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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