Protocadherin-12 (PCDH12)
Homo sapiens — UniProt Q9NPG4
Data last refreshed: (UniProt release unknown)
Key facts
Protocadherin-12 (PCDH12) is a protein from Homo sapiens identified by UniProt accession Q9NPG4, 1184 residues long. MolForge cross-references it against 0 known binders and 110 disease associations.
- UniProt accession: Q9NPG4; gene symbol PCDH12.
- Organism: Homo sapiens.
- Length: 1184 amino acids.
- Top disease associations (Open Targets): Microcephaly - brain defect - spasticity - hypernatremia, diencephalic-mesencephalic junction dysplasia and Microcephaly.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protocadherin-12 |
|---|---|
| UniProt accession | Q9NPG4 |
| Gene | PCDH12 |
| Organism | Homo sapiens |
| Length | 1184 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (110)
Diseases linked to this target (Open Targets).
- Microcephaly - brain defect - spasticity - hypernatremia · score 0.78
- diencephalic-mesencephalic junction dysplasia · score 0.58
- Microcephaly · score 0.42
- Intellectual disability · score 0.42
- epilepsy · score 0.42
- microcephaly · score 0.42
- reticulocyte count · score 0.31
- Dystonia · score 0.27
- Abnormal facial shape · score 0.27
- cerebellar ataxia · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NPG4-F1 | alphafold | PREDICTED | 65.88 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NPG4.
Amino-acid sequence (1184 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PCDH12?
The strongest Open Targets associations for PCDH12 are Microcephaly - brain defect - spasticity - hypernatremia, diencephalic-mesencephalic junction dysplasia, Microcephaly, Intellectual disability and epilepsy.
How long is the PCDH12 protein?
The Homo sapiens PCDH12 protein (UniProt Q9NPG4) is 1184 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NPG4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NPG4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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