Palmitoyltransferase ZDHHC4 (ZDHHC4)
Homo sapiens — UniProt Q9NPG8
Data last refreshed: (UniProt release unknown)
Key facts
Palmitoyltransferase ZDHHC4 (ZDHHC4) is a protein from Homo sapiens identified by UniProt accession Q9NPG8, 344 residues long. MolForge cross-references it against 0 known binders and 104 disease associations.
- UniProt accession: Q9NPG8; gene symbol ZDHHC4.
- Organism: Homo sapiens.
- Length: 344 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, body mass index and mean corpuscular hemoglobin concentration.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Palmitoyltransferase ZDHHC4 |
|---|---|
| UniProt accession | Q9NPG8 |
| Gene | ZDHHC4 |
| Organism | Homo sapiens |
| Length | 344 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (104)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.27
- body mass index · score 0.18
- mean corpuscular hemoglobin concentration · score 0.17
- vital capacity · score 0.12
- neoplasm · score 0.10
- leukocyte count · score 0.10
- body fat percentage · score 0.08
- experimental autoimmune encephalomyelitis · score 0.08
- granulocyte count · score 0.07
- sum of neutrophil and eosinophil counts · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NPG8-F1 | alphafold | PREDICTED | 84.03 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NPG8.
Amino-acid sequence (344 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZDHHC4?
The strongest Open Targets associations for ZDHHC4 are neurodegenerative disease, body mass index, mean corpuscular hemoglobin concentration, vital capacity and neoplasm.
How long is the ZDHHC4 protein?
The Homo sapiens ZDHHC4 protein (UniProt Q9NPG8) is 344 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NPG8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NPG8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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