Polyamine-transporting ATPase 13A2 (ATP13A2)
Homo sapiens — UniProt Q9NQ11
Data last refreshed: (UniProt release unknown)
Key facts
Polyamine-transporting ATPase 13A2 (ATP13A2) is a protein from Homo sapiens identified by UniProt accession Q9NQ11, 1180 residues long. MolForge cross-references it against 0 known binders and 139 disease associations.
- UniProt accession: Q9NQ11; gene symbol ATP13A2.
- Organism: Homo sapiens.
- Length: 1180 amino acids.
- Top disease associations (Open Targets): Kufor-Rakeb syndrome, autosomal recessive spastic paraplegia type 78 and Hereditary late-onset Parkinson disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Polyamine-transporting ATPase 13A2 |
|---|---|
| UniProt accession | Q9NQ11 |
| Gene | ATP13A2 |
| Organism | Homo sapiens |
| Length | 1180 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (139)
Diseases linked to this target (Open Targets).
- Kufor-Rakeb syndrome · score 0.83
- autosomal recessive spastic paraplegia type 78 · score 0.79
- Hereditary late-onset Parkinson disease · score 0.55
- genetic disorder · score 0.53
- Dystonia · score 0.51
- complex hereditary spastic paraplegia · score 0.50
- neurodegeneration with brain iron accumulation · score 0.49
- Parkinson disease · score 0.47
- parkinsonism due to ATP13A2 deficiency · score 0.37
- BMI-adjusted waist circumference · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQ11-F1 | alphafold | PREDICTED | 79.64 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQ11.
Amino-acid sequence (1180 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ATP13A2?
The strongest Open Targets associations for ATP13A2 are Kufor-Rakeb syndrome, autosomal recessive spastic paraplegia type 78, Hereditary late-onset Parkinson disease, genetic disorder and Dystonia.
How long is the ATP13A2 protein?
The Homo sapiens ATP13A2 protein (UniProt Q9NQ11) is 1180 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQ11 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQ11 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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