Endothelial cell-specific molecule 1 (ESM1)
Homo sapiens — UniProt Q9NQ30
Data last refreshed: (UniProt release unknown)
Key facts
Endothelial cell-specific molecule 1 (ESM1) is a protein from Homo sapiens identified by UniProt accession Q9NQ30, 184 residues long. MolForge cross-references it against 0 known binders and 267 disease associations.
- UniProt accession: Q9NQ30; gene symbol ESM1.
- Organism: Homo sapiens.
- Length: 184 amino acids.
- Top disease associations (Open Targets): endothelial cell-specific molecule 1 measurement, stroke and Arterial stenosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Endothelial cell-specific molecule 1 |
|---|---|
| UniProt accession | Q9NQ30 |
| Gene | ESM1 |
| Organism | Homo sapiens |
| Length | 184 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (267)
Diseases linked to this target (Open Targets).
- endothelial cell-specific molecule 1 measurement · score 0.39
- stroke · score 0.31
- Arterial stenosis · score 0.31
- Arterial occlusion · score 0.31
- PHF-tau measurement · score 0.31
- blood protein measurement · score 0.30
- neurodegenerative disease · score 0.25
- breast milk measurement · score 0.24
- FEV/FVC ratio · score 0.12
- neoplasm · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQ30-F1 | alphafold | PREDICTED | 72.69 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQ30.
Amino-acid sequence (184 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ESM1?
The strongest Open Targets associations for ESM1 are endothelial cell-specific molecule 1 measurement, stroke, Arterial stenosis, Arterial occlusion and PHF-tau measurement.
How long is the ESM1 protein?
The Homo sapiens ESM1 protein (UniProt Q9NQ30) is 184 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQ30 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQ30 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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