Achaete-scute homolog 3 (ASCL3)

About Achaete-scute homolog 3

Achaete-scute homolog 3 (ASCL3) is a protein from Homo sapiens identified by UniProt accession Q9NQ33, 181 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.

Target properties

Protein name	Achaete-scute homolog 3
UniProt accession	Q9NQ33
Gene	ASCL3
Organism	Homo sapiens
Length	181 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (35)

Diseases linked to this target (Open Targets).

BMI-adjusted waist-hip ratio · score 0.17
brain measurement · score 0.14
neuroimaging measurement · score 0.13
erythrocyte count · score 0.13
waist-hip ratio · score 0.13
cortical surface area measurement · score 0.10
Red cell distribution width · score 0.10
hematocrit · score 0.08
basophil count · score 0.07
hemoglobin measurement · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NQ33-F1	alphafold	PREDICTED	69.02	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQ33.

Amino-acid sequence (181 residues)

MMDNRGNSSL PDKLPIFPDS ARLPLTRSFY LEPMVTFHVH PEAPVSSPYS EELPRLPFPS DSLILGNYSE PCPFSFPMPY PNYRGCEYSY GPAFTRKRNE RERQRVKCVN EGYAQLRHHL PEEYLEKRLS KVETLRAAIK YINYLQSLLY PDKAETKNNP GKVSSMIATT SHHADPMFRI V

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards