Serine protease inhibitor Kazal-type 5 (SPINK5)
Homo sapiens — UniProt Q9NQ38
Data last refreshed: (UniProt release unknown)
Key facts
Serine protease inhibitor Kazal-type 5 (SPINK5) is a protein from Homo sapiens identified by UniProt accession Q9NQ38, 1064 residues long. MolForge cross-references it against 0 known binders and 298 disease associations.
- UniProt accession: Q9NQ38; gene symbol SPINK5.
- Organism: Homo sapiens.
- Length: 1064 amino acids.
- Top disease associations (Open Targets): Netherton syndrome, ichthyosis linearis circumflexa and atopy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine protease inhibitor Kazal-type 5 |
|---|---|
| UniProt accession | Q9NQ38 |
| Gene | SPINK5 |
| Organism | Homo sapiens |
| Length | 1064 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (298)
Diseases linked to this target (Open Targets).
- Netherton syndrome · score 0.79
- ichthyosis linearis circumflexa · score 0.56
- atopy · score 0.37
- exfoliative dermatitis · score 0.33
- Increased circulating IgE level · score 0.33
- neurodegenerative disease · score 0.29
- blood protein measurement · score 0.25
- breast adenocarcinoma · score 0.22
- head and neck squamous cell carcinoma · score 0.21
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQ38-F1 | alphafold | PREDICTED | 73.97 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQ38.
Amino-acid sequence (1064 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPINK5?
The strongest Open Targets associations for SPINK5 are Netherton syndrome, ichthyosis linearis circumflexa, atopy, exfoliative dermatitis and Increased circulating IgE level.
How long is the SPINK5 protein?
The Homo sapiens SPINK5 protein (UniProt Q9NQ38) is 1064 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQ38 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQ38 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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