Leucine zipper transcription factor-like protein 1 (LZTFL1)
Homo sapiens — UniProt Q9NQ48
Data last refreshed: (UniProt release unknown)
Key facts
Leucine zipper transcription factor-like protein 1 (LZTFL1) is a protein from Homo sapiens identified by UniProt accession Q9NQ48, 299 residues long. MolForge cross-references it against 0 known binders and 250 disease associations.
- UniProt accession: Q9NQ48; gene symbol LZTFL1.
- Organism: Homo sapiens.
- Length: 299 amino acids.
- Top disease associations (Open Targets): Bardet-Biedl syndrome, ciliopathy and Polydactyly.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine zipper transcription factor-like protein 1 |
|---|---|
| UniProt accession | Q9NQ48 |
| Gene | LZTFL1 |
| Organism | Homo sapiens |
| Length | 299 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (250)
Diseases linked to this target (Open Targets).
- Bardet-Biedl syndrome · score 0.77
- ciliopathy · score 0.37
- Polydactyly · score 0.37
- polydactyly · score 0.37
- COVID-19 · score 0.35
- alkaline phosphatase measurement · score 0.23
- blood protein measurement · score 0.22
- respiratory symptom measurement · score 0.19
- pneumonia · score 0.19
- aspartate aminotransferase measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQ48-F1 | alphafold | PREDICTED | 83.52 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQ48.
Amino-acid sequence (299 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LZTFL1?
The strongest Open Targets associations for LZTFL1 are Bardet-Biedl syndrome, ciliopathy, Polydactyly, polydactyly and COVID-19.
How long is the LZTFL1 protein?
The Homo sapiens LZTFL1 protein (UniProt Q9NQ48) is 299 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQ48 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQ48 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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