Suppressor of SWI4 1 homolog (PPAN)
Homo sapiens — UniProt Q9NQ55
Data last refreshed: (UniProt release unknown)
Key facts
Suppressor of SWI4 1 homolog (PPAN) is a protein from Homo sapiens identified by UniProt accession Q9NQ55, 473 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.
- UniProt accession: Q9NQ55; gene symbol PPAN.
- Organism: Homo sapiens.
- Length: 473 amino acids.
- Top disease associations (Open Targets): Parkinson disease, multiple sclerosis and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Suppressor of SWI4 1 homolog |
|---|---|
| UniProt accession | Q9NQ55 |
| Gene | PPAN |
| Organism | Homo sapiens |
| Length | 473 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (19)
Diseases linked to this target (Open Targets).
- Parkinson disease · score 0.46
- multiple sclerosis · score 0.46
- neurodegenerative disease · score 0.46
- lysosomal storage disease · score 0.46
- Alzheimer disease · score 0.46
- narcolepsy-cataplexy syndrome · score 0.44
- heel bone mineral density · score 0.12
- body height · score 0.04
- platelet crit · score 0.04
- ICAM-1 measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQ55-F1 | alphafold | PREDICTED | 72.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQ55.
Amino-acid sequence (473 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PPAN?
The strongest Open Targets associations for PPAN are Parkinson disease, multiple sclerosis, neurodegenerative disease, lysosomal storage disease and Alzheimer disease.
How long is the PPAN protein?
The Homo sapiens PPAN protein (UniProt Q9NQ55) is 473 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQ55 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQ55 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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