1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)
Homo sapiens — UniProt Q9NQ66
Data last refreshed: (UniProt release unknown)
Key facts
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1) is a protein from Homo sapiens identified by UniProt accession Q9NQ66, 1216 residues long. MolForge cross-references it against 0 known binders and 363 disease associations.
- UniProt accession: Q9NQ66; gene symbol PLCB1.
- Organism: Homo sapiens.
- Length: 1216 amino acids.
- Top disease associations (Open Targets): developmental and epileptic encephalopathy, 12, developmental and epileptic encephalopathy and neutrophil count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 |
|---|---|
| UniProt accession | Q9NQ66 |
| Gene | PLCB1 |
| Organism | Homo sapiens |
| Length | 1216 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (363)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy, 12 · score 0.75
- developmental and epileptic encephalopathy · score 0.65
- neutrophil count · score 0.50
- leukocyte count · score 0.49
- monocyte count · score 0.47
- myeloid white cell count · score 0.42
- lymphocyte count · score 0.42
- mean corpuscular volume · score 0.42
- platelet count · score 0.41
- mathematical ability · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQ66-F1 | alphafold | PREDICTED | 83.60 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQ66.
Amino-acid sequence (1216 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLCB1?
The strongest Open Targets associations for PLCB1 are developmental and epileptic encephalopathy, 12, developmental and epileptic encephalopathy, neutrophil count, leukocyte count and monocyte count.
How long is the PLCB1 protein?
The Homo sapiens PLCB1 protein (UniProt Q9NQ66) is 1216 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQ66 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQ66 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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