Matrix extracellular phosphoglycoprotein (MEPE)

About Matrix extracellular phosphoglycoprotein

Matrix extracellular phosphoglycoprotein (MEPE) is a protein from Homo sapiens identified by UniProt accession Q9NQ76, 525 residues long. MolForge cross-references it against 0 known binders and 73 disease associations.

Target properties

Protein name	Matrix extracellular phosphoglycoprotein
UniProt accession	Q9NQ76
Gene	MEPE
Organism	Homo sapiens
Length	525 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (73)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.72
bone quantitative ultrasound measurement · score 0.70
velocity of sound measurement · score 0.57
bone density · score 0.47
otosclerosis · score 0.43
blood phosphate measurement · score 0.34
serum gamma-glutamyl transferase measurement · score 0.32
osteoporosis · score 0.27
Genetic renal or urinary tract malformation · score 0.26
lean body mass · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NQ76-F1	alphafold	PREDICTED	43.27	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQ76.

Amino-acid sequence (525 residues)

MRVFCVGLLL FSVTWAAPTF QPQTEKTKQS CVEEQRQEEK NKDNIGFHHL GKRINQELSS KENIVQERKK DLSLSEASEN KGSSKSQNYF TNRQRLNKEY SISNKENTHN GLRMSIYPKS TGNKGFEDGD DAISKLHDQE EYGAALIRNN MQHIMGPVTA IKLLGEENKE NTPRNVLNII PASMNYAKAH SKDKKKPQRD SQAQKSPVKS KSTHRIQHNI DYLKHLSKVK KIPSDFEGSG YTDLQERGDN DISPFSGDGQ PFKDIPGKGE ATGPDLEGKD IQTGFAGPSE AESTHLDTKK PGYNEIPERE ENGGNTIGTR DETAKEADAV DVSLVEGSND IMGSTNFKEL PGREGNRVDA GSQNAHQGKV EFHYPPAPSK EKRKEGSSDA AESTNYNEIP KNGKGSTRKG VDHSNRNQAT LNEKQRFPSK GKSQGLPIPS RGLDNEIKNE MDSFNGPSHE NIITHGRKYH YVPHRQNNST RNKGMPQGKG SWGRQPHSNR RFSSRRRDDS SESSDSGSSS ESDGD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards