Hairy/enhancer-of-split related with YRPW motif-like protein (HEYL)
Homo sapiens — UniProt Q9NQ87
Data last refreshed: (UniProt release unknown)
Key facts
Hairy/enhancer-of-split related with YRPW motif-like protein (HEYL) is a protein from Homo sapiens identified by UniProt accession Q9NQ87, 328 residues long. MolForge cross-references it against 0 known binders and 81 disease associations.
- UniProt accession: Q9NQ87; gene symbol HEYL.
- Organism: Homo sapiens.
- Length: 328 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, head and neck squamous cell carcinoma and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Hairy/enhancer-of-split related with YRPW motif-like protein |
|---|---|
| UniProt accession | Q9NQ87 |
| Gene | HEYL |
| Organism | Homo sapiens |
| Length | 328 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (81)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- head and neck squamous cell carcinoma · score 0.25
- breast adenocarcinoma · score 0.24
- thyroid gland adenocarcinoma · score 0.23
- endometrial cancer · score 0.18
- neoplasm · score 0.10
- COVID-19 · score 0.07
- breast cancer · score 0.05
- chronic obstructive pulmonary disease · score 0.05
- type 2 diabetes mellitus · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQ87-F1 | alphafold | PREDICTED | 64.96 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQ87.
Amino-acid sequence (328 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HEYL?
The strongest Open Targets associations for HEYL are neurodegenerative disease, head and neck squamous cell carcinoma, breast adenocarcinoma, thyroid gland adenocarcinoma and endometrial cancer.
How long is the HEYL protein?
The Homo sapiens HEYL protein (UniProt Q9NQ87) is 328 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQ87 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQ87 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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