Fructose-2,6-bisphosphatase TIGAR (TIGAR)
Homo sapiens — UniProt Q9NQ88
Data last refreshed: (UniProt release unknown)
Key facts
Fructose-2,6-bisphosphatase TIGAR (TIGAR) is a protein from Homo sapiens identified by UniProt accession Q9NQ88, 270 residues long. MolForge cross-references it against 0 known binders and 173 disease associations.
- UniProt accession: Q9NQ88; gene symbol TIGAR.
- Organism: Homo sapiens.
- Length: 270 amino acids.
- Top disease associations (Open Targets): body height, lean body mass and creatinine measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Fructose-2,6-bisphosphatase TIGAR |
|---|---|
| UniProt accession | Q9NQ88 |
| Gene | TIGAR |
| Organism | Homo sapiens |
| Length | 270 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (173)
Diseases linked to this target (Open Targets).
- body height · score 0.30
- lean body mass · score 0.29
- creatinine measurement · score 0.27
- type 2 diabetes mellitus · score 0.25
- fat body mass · score 0.23
- breast adenocarcinoma · score 0.23
- cystatin C measurement · score 0.21
- sex hormone-binding globulin measurement · score 0.19
- eosinophil count · score 0.19
- head and neck squamous cell carcinoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQ88-F1 | alphafold | PREDICTED | 89.73 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQ88.
Amino-acid sequence (270 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TIGAR?
The strongest Open Targets associations for TIGAR are body height, lean body mass, creatinine measurement, type 2 diabetes mellitus and fat body mass.
How long is the TIGAR protein?
The Homo sapiens TIGAR protein (UniProt Q9NQ88) is 270 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQ88 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQ88 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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