APOBEC1 complementation factor (A1CF)
Homo sapiens — UniProt Q9NQ94
Data last refreshed: (UniProt release unknown)
Key facts
APOBEC1 complementation factor (A1CF) is a protein from Homo sapiens identified by UniProt accession Q9NQ94, 594 residues long. MolForge cross-references it against 0 known binders and 277 disease associations.
- UniProt accession: Q9NQ94; gene symbol A1CF.
- Organism: Homo sapiens.
- Length: 594 amino acids.
- Top disease associations (Open Targets): serum gamma-glutamyl transferase measurement, urate measurement and creatinine measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | APOBEC1 complementation factor |
|---|---|
| UniProt accession | Q9NQ94 |
| Gene | A1CF |
| Organism | Homo sapiens |
| Length | 594 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (277)
Diseases linked to this target (Open Targets).
- serum gamma-glutamyl transferase measurement · score 0.63
- urate measurement · score 0.50
- creatinine measurement · score 0.46
- triglyceride measurement · score 0.45
- glomerular filtration rate · score 0.43
- low density lipoprotein cholesterol measurement · score 0.42
- apolipoprotein B measurement · score 0.40
- glucose measurement · score 0.40
- uric acid measurement · score 0.35
- total blood protein measurement · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQ94-F1 | alphafold | PREDICTED | 68.80 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQ94.
Amino-acid sequence (594 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with A1CF?
The strongest Open Targets associations for A1CF are serum gamma-glutamyl transferase measurement, urate measurement, creatinine measurement, triglyceride measurement and glomerular filtration rate.
How long is the A1CF protein?
The Homo sapiens A1CF protein (UniProt Q9NQ94) is 594 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQ94 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQ94 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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