E3 ubiquitin-protein ligase Jade-2 (JADE2)
Homo sapiens — UniProt Q9NQC1
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase Jade-2 (JADE2) is a protein from Homo sapiens identified by UniProt accession Q9NQC1, 790 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.
- UniProt accession: Q9NQC1; gene symbol JADE2.
- Organism: Homo sapiens.
- Length: 790 amino acids.
- Top disease associations (Open Targets): age at menarche, body mass index and calcium measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase Jade-2 |
|---|---|
| UniProt accession | Q9NQC1 |
| Gene | JADE2 |
| Organism | Homo sapiens |
| Length | 790 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (83)
Diseases linked to this target (Open Targets).
- age at menarche · score 0.46
- body mass index · score 0.43
- calcium measurement · score 0.42
- sex hormone-binding globulin measurement · score 0.42
- age at first birth measurement · score 0.41
- type 2 diabetes mellitus · score 0.41
- electrocardiography · score 0.40
- bipolar disorder · score 0.40
- body fat percentage · score 0.39
- monocyte count · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQC1-F1 | alphafold | PREDICTED | 61.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQC1.
Amino-acid sequence (790 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with JADE2?
The strongest Open Targets associations for JADE2 are age at menarche, body mass index, calcium measurement, sex hormone-binding globulin measurement and age at first birth measurement.
How long is the JADE2 protein?
The Homo sapiens JADE2 protein (UniProt Q9NQC1) is 790 amino acids long.
Browse: Targets: J · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQC1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQC1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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