Reticulon-4 (RTN4)
Homo sapiens — UniProt Q9NQC3
Data last refreshed: (UniProt release unknown)
Key facts
Reticulon-4 (RTN4) is a protein from Homo sapiens identified by UniProt accession Q9NQC3, 1192 residues long. MolForge cross-references it against 0 known binders and 172 disease associations.
- UniProt accession: Q9NQC3; gene symbol RTN4.
- Organism: Homo sapiens.
- Length: 1192 amino acids.
- Top disease associations (Open Targets): body mass index, platelet count and body fat percentage.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Reticulon-4 |
|---|---|
| UniProt accession | Q9NQC3 |
| Gene | RTN4 |
| Organism | Homo sapiens |
| Length | 1192 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (172)
Diseases linked to this target (Open Targets).
- body mass index · score 0.47
- platelet count · score 0.45
- body fat percentage · score 0.43
- lymphocyte count · score 0.42
- fat body mass · score 0.39
- systolic blood pressure · score 0.36
- lean body mass · score 0.35
- sex hormone-binding globulin measurement · score 0.32
- body height · score 0.31
- Red cell distribution width · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQC3-F1 | alphafold | PREDICTED | 40.84 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQC3.
Amino-acid sequence (1192 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RTN4?
The strongest Open Targets associations for RTN4 are body mass index, platelet count, body fat percentage, lymphocyte count and fat body mass.
How long is the RTN4 protein?
The Homo sapiens RTN4 protein (UniProt Q9NQC3) is 1192 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQC3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQC3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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