Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD)
Homo sapiens — UniProt Q9NQC7
Data last refreshed: (UniProt release unknown)
Key facts
Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD) is a protein from Homo sapiens identified by UniProt accession Q9NQC7, 956 residues long. MolForge cross-references it against 0 known binders and 598 disease associations.
- UniProt accession: Q9NQC7; gene symbol CYLD.
- Organism: Homo sapiens.
- Length: 956 amino acids.
- Top disease associations (Open Targets): familial cylindromatosis, Brooke-Spiegler syndrome and familial multiple trichoepithelioma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubiquitin carboxyl-terminal hydrolase CYLD |
|---|---|
| UniProt accession | Q9NQC7 |
| Gene | CYLD |
| Organism | Homo sapiens |
| Length | 956 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (598)
Diseases linked to this target (Open Targets).
- familial cylindromatosis · score 0.75
- Brooke-Spiegler syndrome · score 0.70
- familial multiple trichoepithelioma · score 0.59
- frontotemporal dementia and/or amyotrophic lateral sclerosis · score 0.52
- multiple myeloma · score 0.50
- benign neoplasm of skin · score 0.46
- Crohn's disease · score 0.42
- inflammatory bowel disease · score 0.41
- benign spiradenoma · score 0.37
- skin basal cell carcinoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQC7-F1 | alphafold | PREDICTED | 74.43 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQC7.
Amino-acid sequence (956 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CYLD?
The strongest Open Targets associations for CYLD are familial cylindromatosis, Brooke-Spiegler syndrome, familial multiple trichoepithelioma, frontotemporal dementia and/or amyotrophic lateral sclerosis and multiple myeloma.
How long is the CYLD protein?
The Homo sapiens CYLD protein (UniProt Q9NQC7) is 956 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQC7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQC7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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