Intraflagellar transport protein 46 homolog (IFT46)
Homo sapiens — UniProt Q9NQC8
Data last refreshed: (UniProt release unknown)
Key facts
Intraflagellar transport protein 46 homolog (IFT46) is a protein from Homo sapiens identified by UniProt accession Q9NQC8, 304 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.
- UniProt accession: Q9NQC8; gene symbol IFT46.
- Organism: Homo sapiens.
- Length: 304 amino acids.
- Top disease associations (Open Targets): total cholesterol measurement, high density lipoprotein cholesterol measurement and psoriasis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Intraflagellar transport protein 46 homolog |
|---|---|
| UniProt accession | Q9NQC8 |
| Gene | IFT46 |
| Organism | Homo sapiens |
| Length | 304 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (29)
Diseases linked to this target (Open Targets).
- total cholesterol measurement · score 0.17
- high density lipoprotein cholesterol measurement · score 0.13
- psoriasis · score 0.12
- apolipoprotein A 1 measurement · score 0.10
- low density lipoprotein cholesterol measurement · score 0.09
- cyst · score 0.04
- myeloid white cell count · score 0.03
- neutrophil count · score 0.03
- leukocyte count · score 0.03
- primary ciliary dyskinesia · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQC8-F1 | alphafold | PREDICTED | 69.72 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQC8.
Amino-acid sequence (304 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IFT46?
The strongest Open Targets associations for IFT46 are total cholesterol measurement, high density lipoprotein cholesterol measurement, psoriasis, apolipoprotein A 1 measurement and low density lipoprotein cholesterol measurement.
How long is the IFT46 protein?
The Homo sapiens IFT46 protein (UniProt Q9NQC8) is 304 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQC8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQC8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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