BLOC-3 complex member HPS4 (HPS4)
Homo sapiens — UniProt Q9NQG7
Data last refreshed: (UniProt release unknown)
Key facts
BLOC-3 complex member HPS4 (HPS4) is a protein from Homo sapiens identified by UniProt accession Q9NQG7, 708 residues long. MolForge cross-references it against 0 known binders and 169 disease associations.
- UniProt accession: Q9NQG7; gene symbol HPS4.
- Organism: Homo sapiens.
- Length: 708 amino acids.
- Top disease associations (Open Targets): Hermansky-Pudlak syndrome with pulmonary fibrosis, Hermansky-Pudlak syndrome and albinism.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | BLOC-3 complex member HPS4 |
|---|---|
| UniProt accession | Q9NQG7 |
| Gene | HPS4 |
| Organism | Homo sapiens |
| Length | 708 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (169)
Diseases linked to this target (Open Targets).
- Hermansky-Pudlak syndrome with pulmonary fibrosis · score 0.79
- Hermansky-Pudlak syndrome · score 0.63
- albinism · score 0.43
- lung disease · score 0.37
- genetic disorder · score 0.34
- blood protein measurement · score 0.22
- oculocutaneous albinism · score 0.12
- interstitial lung disease · score 0.11
- Griscelli syndrome type 3 · score 0.07
- Tietz syndrome · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQG7-F1 | alphafold | PREDICTED | 61.64 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQG7.
Amino-acid sequence (708 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HPS4?
The strongest Open Targets associations for HPS4 are Hermansky-Pudlak syndrome with pulmonary fibrosis, Hermansky-Pudlak syndrome, albinism, lung disease and genetic disorder.
How long is the HPS4 protein?
The Homo sapiens HPS4 protein (UniProt Q9NQG7) is 708 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQG7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQG7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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