Probable ATP-dependent RNA helicase DDX4 (DDX4)
Homo sapiens — UniProt Q9NQI0
Data last refreshed: (UniProt release unknown)
Key facts
Probable ATP-dependent RNA helicase DDX4 (DDX4) is a protein from Homo sapiens identified by UniProt accession Q9NQI0, 724 residues long. MolForge cross-references it against 0 known binders and 166 disease associations.
- UniProt accession: Q9NQI0; gene symbol DDX4.
- Organism: Homo sapiens.
- Length: 724 amino acids.
- Top disease associations (Open Targets): neutrophil count, BMI-adjusted waist-hip ratio and BMI-adjusted waist circumference.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Probable ATP-dependent RNA helicase DDX4 |
|---|---|
| UniProt accession | Q9NQI0 |
| Gene | DDX4 |
| Organism | Homo sapiens |
| Length | 724 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (166)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.22
- BMI-adjusted waist-hip ratio · score 0.20
- BMI-adjusted waist circumference · score 0.18
- body height · score 0.17
- waist-hip ratio · score 0.16
- lean body mass · score 0.16
- appendicular lean mass · score 0.16
- cutaneous melanoma · score 0.15
- serum gamma-glutamyl transferase measurement · score 0.15
- fat body mass · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQI0-F1 | alphafold | PREDICTED | 68.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQI0.
Amino-acid sequence (724 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DDX4?
The strongest Open Targets associations for DDX4 are neutrophil count, BMI-adjusted waist-hip ratio, BMI-adjusted waist circumference, body height and waist-hip ratio.
How long is the DDX4 protein?
The Homo sapiens DDX4 protein (UniProt Q9NQI0) is 724 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQI0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQI0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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