Dynein axonemal assembly factor 6 (DNAAF6)
Homo sapiens — UniProt Q9NQM4
Data last refreshed: (UniProt release unknown)
Key facts
Dynein axonemal assembly factor 6 (DNAAF6) is a protein from Homo sapiens identified by UniProt accession Q9NQM4, 214 residues long. MolForge cross-references it against 0 known binders and 97 disease associations.
- UniProt accession: Q9NQM4; gene symbol DNAAF6.
- Organism: Homo sapiens.
- Length: 214 amino acids.
- Top disease associations (Open Targets): primary ciliary dyskinesia, genetic disorder and azoospermia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dynein axonemal assembly factor 6 |
|---|---|
| UniProt accession | Q9NQM4 |
| Gene | DNAAF6 |
| Organism | Homo sapiens |
| Length | 214 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (97)
Diseases linked to this target (Open Targets).
- primary ciliary dyskinesia · score 0.64
- genetic disorder · score 0.12
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- partial chromosome Y deletion · score 0.07
- spermatogenic failure 72 · score 0.07
- spermatogenic failure 46 · score 0.07
- spermatogenic failure 18 · score 0.07
- spermatogenic failure 27 · score 0.07
- spermatogenic failure 49 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQM4-F1 | alphafold | PREDICTED | 73.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQM4.
Amino-acid sequence (214 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DNAAF6?
The strongest Open Targets associations for DNAAF6 are primary ciliary dyskinesia, genetic disorder, azoospermia, male infertility with teratozoospermia due to single gene mutation and partial chromosome Y deletion.
How long is the DNAAF6 protein?
The Homo sapiens DNAAF6 protein (UniProt Q9NQM4) is 214 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQM4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQM4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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