Prefoldin subunit 4 (PFDN4)
Homo sapiens — UniProt Q9NQP4
Data last refreshed: (UniProt release unknown)
Key facts
Prefoldin subunit 4 (PFDN4) is a protein from Homo sapiens identified by UniProt accession Q9NQP4, 134 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.
- UniProt accession: Q9NQP4; gene symbol PFDN4.
- Organism: Homo sapiens.
- Length: 134 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, glioblastoma multiforme and gastric adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Prefoldin subunit 4 |
|---|---|
| UniProt accession | Q9NQP4 |
| Gene | PFDN4 |
| Organism | Homo sapiens |
| Length | 134 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (62)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- glioblastoma multiforme · score 0.23
- gastric adenocarcinoma · score 0.23
- gut microbiome measurement · score 0.18
- colorectal cancer · score 0.14
- vitamin D measurement · score 0.08
- atopic eczema · score 0.08
- calcium measurement · score 0.07
- nephrolithiasis · score 0.07
- glomerular filtration rate · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQP4-F1 | alphafold | PREDICTED | 87.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQP4.
Amino-acid sequence (134 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PFDN4?
The strongest Open Targets associations for PFDN4 are neurodegenerative disease, glioblastoma multiforme, gastric adenocarcinoma, gut microbiome measurement and colorectal cancer.
How long is the PFDN4 protein?
The Homo sapiens PFDN4 protein (UniProt Q9NQP4) is 134 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQP4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQP4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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