N-lysine methyltransferase KMT5A (KMT5A)
Homo sapiens — UniProt Q9NQR1
Data last refreshed: (UniProt release unknown)
Key facts
N-lysine methyltransferase KMT5A (KMT5A) is a protein from Homo sapiens identified by UniProt accession Q9NQR1, 393 residues long. MolForge cross-references it against 0 known binders and 178 disease associations.
- UniProt accession: Q9NQR1; gene symbol KMT5A.
- Organism: Homo sapiens.
- Length: 393 amino acids.
- Top disease associations (Open Targets): high density lipoprotein cholesterol measurement, breast adenocarcinoma and apolipoprotein A 1 measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | N-lysine methyltransferase KMT5A |
|---|---|
| UniProt accession | Q9NQR1 |
| Gene | KMT5A |
| Organism | Homo sapiens |
| Length | 393 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (178)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.33
- breast adenocarcinoma · score 0.32
- apolipoprotein A 1 measurement · score 0.30
- lymphocyte count · score 0.26
- appendicular lean mass · score 0.25
- low grade glioma · score 0.25
- eosinophil count · score 0.23
- endometrial cancer · score 0.22
- head and neck squamous cell carcinoma · score 0.21
- myeloid white cell count · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQR1-F1 | alphafold | PREDICTED | 64.50 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQR1.
Amino-acid sequence (393 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KMT5A?
The strongest Open Targets associations for KMT5A are high density lipoprotein cholesterol measurement, breast adenocarcinoma, apolipoprotein A 1 measurement, lymphocyte count and appendicular lean mass.
How long is the KMT5A protein?
The Homo sapiens KMT5A protein (UniProt Q9NQR1) is 393 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQR1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQR1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.