Glucose-6-phosphatase 2 (G6PC2)
Homo sapiens — UniProt Q9NQR9
Data last refreshed: (UniProt release unknown)
Key facts
Glucose-6-phosphatase 2 (G6PC2) is a protein from Homo sapiens identified by UniProt accession Q9NQR9, 355 residues long. MolForge cross-references it against 0 known binders and 112 disease associations.
- UniProt accession: Q9NQR9; gene symbol G6PC2.
- Organism: Homo sapiens.
- Length: 355 amino acids.
- Top disease associations (Open Targets): glucose measurement, HbA1c measurement and fasting blood glucose measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Glucose-6-phosphatase 2 |
|---|---|
| UniProt accession | Q9NQR9 |
| Gene | G6PC2 |
| Organism | Homo sapiens |
| Length | 355 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (112)
Diseases linked to this target (Open Targets).
- glucose measurement · score 0.68
- HbA1c measurement · score 0.67
- fasting blood glucose measurement · score 0.48
- BMI-adjusted fasting blood glucose measurement · score 0.42
- pulse pressure measurement · score 0.39
- birth weight · score 0.33
- HOMA-B · score 0.32
- hemoglobin A1 measurement · score 0.30
- body mass index · score 0.29
- metabolite measurement · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQR9-F1 | alphafold | PREDICTED | 89.80 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQR9.
Amino-acid sequence (355 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with G6PC2?
The strongest Open Targets associations for G6PC2 are glucose measurement, HbA1c measurement, fasting blood glucose measurement, BMI-adjusted fasting blood glucose measurement and pulse pressure measurement.
How long is the G6PC2 protein?
The Homo sapiens G6PC2 protein (UniProt Q9NQR9) is 355 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQR9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQR9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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