G-protein coupled receptor 84 (GPR84)
Homo sapiens — UniProt Q9NQS5
Data last refreshed: (UniProt release unknown)
Key facts
G-protein coupled receptor 84 (GPR84) is a protein from Homo sapiens identified by UniProt accession Q9NQS5, 396 residues long. MolForge cross-references it against 2 known binders and 144 disease associations.
- UniProt accession: Q9NQS5; gene symbol GPR84.
- Organism: Homo sapiens.
- Length: 396 amino acids.
- Approved drugs acting on it (DrugCentral): Dodecanoic Acid.
- Top disease associations (Open Targets): neoplasm, ulcerative colitis and platelet-derived growth factor BB measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | G-protein coupled receptor 84 |
|---|---|
| UniProt accession | Q9NQS5 |
| Gene | GPR84 |
| Organism | Homo sapiens |
| Length | 396 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (144)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.10
- ulcerative colitis · score 0.09
- platelet-derived growth factor BB measurement · score 0.09
- platelet count · score 0.09
- calcium measurement · score 0.08
- idiopathic pulmonary fibrosis · score 0.07
- colitis · score 0.07
- non-alcoholic steatohepatitis · score 0.07
- Alstrom syndrome · score 0.07
- blood protein measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQS5-F1 | alphafold | PREDICTED | 80.72 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQS5.
Amino-acid sequence (396 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target GPR84?
DrugCentral lists 1 approved drug whose mechanism of action is GPR84: Dodecanoic Acid.
Which diseases are associated with GPR84?
The strongest Open Targets associations for GPR84 are neoplasm, ulcerative colitis, platelet-derived growth factor BB measurement, platelet count and calcium measurement.
How long is the GPR84 protein?
The Homo sapiens GPR84 protein (UniProt Q9NQS5) is 396 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQS5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQS5 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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