Exosome complex component RRP46 (EXOSC5)
Homo sapiens — UniProt Q9NQT4
Data last refreshed: (UniProt release unknown)
Key facts
Exosome complex component RRP46 (EXOSC5) is a protein from Homo sapiens identified by UniProt accession Q9NQT4, 235 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.
- UniProt accession: Q9NQT4; gene symbol EXOSC5.
- Organism: Homo sapiens.
- Length: 235 amino acids.
- Top disease associations (Open Targets): cerebellar ataxia, brain abnormalities, and cardiac conduction defects, neurodegenerative disease and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Exosome complex component RRP46 |
|---|---|
| UniProt accession | Q9NQT4 |
| Gene | EXOSC5 |
| Organism | Homo sapiens |
| Length | 235 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (58)
Diseases linked to this target (Open Targets).
- cerebellar ataxia, brain abnormalities, and cardiac conduction defects · score 0.70
- neurodegenerative disease · score 0.50
- genetic disorder · score 0.19
- Cerebellar hypoplasia · score 0.18
- Ataxia · score 0.18
- Short stature · score 0.18
- reticulocyte count · score 0.18
- reticulocyte measurement · score 0.14
- hair color · score 0.14
- maple syrup urine disease · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQT4-F1 | alphafold | PREDICTED | 84.43 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQT4.
Amino-acid sequence (235 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EXOSC5?
The strongest Open Targets associations for EXOSC5 are cerebellar ataxia, brain abnormalities, and cardiac conduction defects, neurodegenerative disease, genetic disorder, Cerebellar hypoplasia and Ataxia.
How long is the EXOSC5 protein?
The Homo sapiens EXOSC5 protein (UniProt Q9NQT4) is 235 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQT4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQT4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.