Exosome complex component RRP40 (EXOSC3)
Homo sapiens — UniProt Q9NQT5
Data last refreshed: (UniProt release unknown)
Key facts
Exosome complex component RRP40 (EXOSC3) is a protein from Homo sapiens identified by UniProt accession Q9NQT5, 275 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.
- UniProt accession: Q9NQT5; gene symbol EXOSC3.
- Organism: Homo sapiens.
- Length: 275 amino acids.
- Top disease associations (Open Targets): pontocerebellar hypoplasia type 1, neurodegenerative disease and Non-syndromic pontocerebellar hypoplasia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Exosome complex component RRP40 |
|---|---|
| UniProt accession | Q9NQT5 |
| Gene | EXOSC3 |
| Organism | Homo sapiens |
| Length | 275 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (62)
Diseases linked to this target (Open Targets).
- pontocerebellar hypoplasia type 1 · score 0.73
- neurodegenerative disease · score 0.53
- Non-syndromic pontocerebellar hypoplasia · score 0.48
- pontocerebellar hypoplasia · score 0.48
- genetic disorder · score 0.41
- Microcephaly · score 0.34
- Abnormality of the nervous system · score 0.34
- fetal akinesia deformation sequence · score 0.34
- Hypotonia · score 0.34
- Lissencephaly · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQT5-F1 | alphafold | PREDICTED | 79.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQT5.
Amino-acid sequence (275 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EXOSC3?
The strongest Open Targets associations for EXOSC3 are pontocerebellar hypoplasia type 1, neurodegenerative disease, Non-syndromic pontocerebellar hypoplasia, pontocerebellar hypoplasia and genetic disorder.
How long is the EXOSC3 protein?
The Homo sapiens EXOSC3 protein (UniProt Q9NQT5) is 275 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQT5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQT5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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