Serine/threonine-protein kinase PAK 6 (PAK6)
Homo sapiens — UniProt Q9NQU5
Data last refreshed: (UniProt release unknown)
Key facts
Serine/threonine-protein kinase PAK 6 (PAK6) is a protein from Homo sapiens identified by UniProt accession Q9NQU5, 681 residues long. MolForge cross-references it against 5 known binders and 90 disease associations.
- UniProt accession: Q9NQU5; gene symbol PAK6.
- Organism: Homo sapiens.
- Length: 681 amino acids.
- Top disease associations (Open Targets): mosaic variegated aneuploidy syndrome, premature chromatid separation trait and neuroinflammatory disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine/threonine-protein kinase PAK 6 |
|---|---|
| UniProt accession | Q9NQU5 |
| Gene | PAK6 |
| Organism | Homo sapiens |
| Length | 681 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (90)
Diseases linked to this target (Open Targets).
- mosaic variegated aneuploidy syndrome · score 0.50
- premature chromatid separation trait · score 0.25
- neuroinflammatory disorder · score 0.20
- genetic disorder · score 0.19
- colorectal cancer · score 0.15
- cutaneous melanoma · score 0.12
- lung adenocarcinoma · score 0.12
- Microcephaly · score 0.11
- keratoconus · score 0.11
- head and neck squamous cell carcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQU5-F1 | alphafold | PREDICTED | 65.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQU5.
Amino-acid sequence (681 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PAK6?
The strongest Open Targets associations for PAK6 are mosaic variegated aneuploidy syndrome, premature chromatid separation trait, neuroinflammatory disorder, genetic disorder and colorectal cancer.
How long is the PAK6 protein?
The Homo sapiens PAK6 protein (UniProt Q9NQU5) is 681 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQU5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQU5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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