Histone-lysine N-methyltransferase PRDM9 (PRDM9)
Homo sapiens — UniProt Q9NQV7
Data last refreshed: (UniProt release unknown)
Key facts
Histone-lysine N-methyltransferase PRDM9 (PRDM9) is a protein from Homo sapiens identified by UniProt accession Q9NQV7, 894 residues long. MolForge cross-references it against 0 known binders and 463 disease associations.
- UniProt accession: Q9NQV7; gene symbol PRDM9.
- Organism: Homo sapiens.
- Length: 894 amino acids.
- Top disease associations (Open Targets): genetic non-acquired premature ovarian failure, recombination rate and recombination measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Histone-lysine N-methyltransferase PRDM9 |
|---|---|
| UniProt accession | Q9NQV7 |
| Gene | PRDM9 |
| Organism | Homo sapiens |
| Length | 894 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (463)
Diseases linked to this target (Open Targets).
- genetic non-acquired premature ovarian failure · score 0.46
- recombination rate · score 0.40
- recombination measurement · score 0.35
- breast adenocarcinoma · score 0.26
- head and neck squamous cell carcinoma · score 0.23
- mathematical ability · score 0.22
- acute myeloid leukemia · score 0.19
- lung adenocarcinoma · score 0.19
- ovarian cancer · score 0.12
- azoospermia · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQV7-F1 | alphafold | PREDICTED | 69.90 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQV7.
Amino-acid sequence (894 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PRDM9?
The strongest Open Targets associations for PRDM9 are genetic non-acquired premature ovarian failure, recombination rate, recombination measurement, breast adenocarcinoma and head and neck squamous cell carcinoma.
How long is the PRDM9 protein?
The Homo sapiens PRDM9 protein (UniProt Q9NQV7) is 894 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQV7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQV7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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