PR domain zinc finger protein 8 (PRDM8)
Homo sapiens — UniProt Q9NQV8
Data last refreshed: (UniProt release unknown)
Key facts
PR domain zinc finger protein 8 (PRDM8) is a protein from Homo sapiens identified by UniProt accession Q9NQV8, 689 residues long. MolForge cross-references it against 0 known binders and 160 disease associations.
- UniProt accession: Q9NQV8; gene symbol PRDM8.
- Organism: Homo sapiens.
- Length: 689 amino acids.
- Top disease associations (Open Targets): early-onset Lafora body disease, neurodegenerative disease and Progressive myoclonic epilepsy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | PR domain zinc finger protein 8 |
|---|---|
| UniProt accession | Q9NQV8 |
| Gene | PRDM8 |
| Organism | Homo sapiens |
| Length | 689 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (160)
Diseases linked to this target (Open Targets).
- early-onset Lafora body disease · score 0.55
- neurodegenerative disease · score 0.43
- Progressive myoclonic epilepsy · score 0.41
- systolic blood pressure · score 0.23
- diastolic blood pressure · score 0.22
- mean arterial pressure · score 0.21
- alcohol drinking · score 0.20
- hypertension · score 0.20
- pulse pressure measurement · score 0.20
- smoking status measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQV8-F1 | alphafold | PREDICTED | 53.53 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQV8.
Amino-acid sequence (689 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PRDM8?
The strongest Open Targets associations for PRDM8 are early-onset Lafora body disease, neurodegenerative disease, Progressive myoclonic epilepsy, systolic blood pressure and diastolic blood pressure.
How long is the PRDM8 protein?
The Homo sapiens PRDM8 protein (UniProt Q9NQV8) is 689 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQV8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQV8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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