Cyclic nucleotide-gated channel beta-3 (CNGB3)
Homo sapiens — UniProt Q9NQW8
Data last refreshed: (UniProt release unknown)
Key facts
Cyclic nucleotide-gated channel beta-3 (CNGB3) is a protein from Homo sapiens identified by UniProt accession Q9NQW8, 809 residues long. MolForge cross-references it against 0 known binders and 73 disease associations.
- UniProt accession: Q9NQW8; gene symbol CNGB3.
- Organism: Homo sapiens.
- Length: 809 amino acids.
- Top disease associations (Open Targets): achromatopsia, severe early-childhood-onset retinal dystrophy and Retinal dystrophy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cyclic nucleotide-gated channel beta-3 |
|---|---|
| UniProt accession | Q9NQW8 |
| Gene | CNGB3 |
| Organism | Homo sapiens |
| Length | 809 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (73)
Diseases linked to this target (Open Targets).
- achromatopsia · score 0.76
- severe early-childhood-onset retinal dystrophy · score 0.58
- Retinal dystrophy · score 0.53
- genetic disorder · score 0.47
- Abnormality of the eye · score 0.47
- Stargardt disease · score 0.46
- Leber congenital amaurosis · score 0.45
- self reported educational attainment · score 0.43
- age at first sexual intercourse measurement · score 0.39
- retinitis pigmentosa · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQW8-F1 | alphafold | PREDICTED | 68.10 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQW8.
Amino-acid sequence (809 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CNGB3?
The strongest Open Targets associations for CNGB3 are achromatopsia, severe early-childhood-onset retinal dystrophy, Retinal dystrophy, genetic disorder and Abnormality of the eye.
How long is the CNGB3 protein?
The Homo sapiens CNGB3 protein (UniProt Q9NQW8) is 809 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQW8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQW8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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