Deleted in azoospermia protein 1 (DAZ1)
Homo sapiens — UniProt Q9NQZ3
Data last refreshed: (UniProt release unknown)
Key facts
Deleted in azoospermia protein 1 (DAZ1) is a protein from Homo sapiens identified by UniProt accession Q9NQZ3, 744 residues long. MolForge cross-references it against 0 known binders and 150 disease associations.
- UniProt accession: Q9NQZ3; gene symbol DAZ1.
- Organism: Homo sapiens.
- Length: 744 amino acids.
- Top disease associations (Open Targets): azoospermia, male infertility with teratozoospermia due to single gene mutation and partial chromosome Y deletion.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Deleted in azoospermia protein 1 |
|---|---|
| UniProt accession | Q9NQZ3 |
| Gene | DAZ1 |
| Organism | Homo sapiens |
| Length | 744 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (150)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- partial chromosome Y deletion · score 0.08
- spermatogenic failure 1 · score 0.08
- spermatogenic failure 48 · score 0.07
- primary ovarian insufficiency · score 0.07
- spermatogenic failure 25 · score 0.07
- spermatogenic failure 22 · score 0.07
- spermatogenic failures 50 · score 0.07
- spermatogenic failure, X-linked, 3 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQZ3-F1 | alphafold | PREDICTED | 57.70 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQZ3.
Amino-acid sequence (744 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DAZ1?
The strongest Open Targets associations for DAZ1 are azoospermia, male infertility with teratozoospermia due to single gene mutation, partial chromosome Y deletion, spermatogenic failure 1 and spermatogenic failure 48.
How long is the DAZ1 protein?
The Homo sapiens DAZ1 protein (UniProt Q9NQZ3) is 744 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQZ3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQZ3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.