Zinc finger C4H2 domain-containing protein (ZC4H2)
Homo sapiens — UniProt Q9NQZ6
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger C4H2 domain-containing protein (ZC4H2) is a protein from Homo sapiens identified by UniProt accession Q9NQZ6, 224 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.
- UniProt accession: Q9NQZ6; gene symbol ZC4H2.
- Organism: Homo sapiens.
- Length: 224 amino acids.
- Top disease associations (Open Targets): Intellectual disability-developmental delay-contractures syndrome, Wieacker-Wolff syndrome and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger C4H2 domain-containing protein |
|---|---|
| UniProt accession | Q9NQZ6 |
| Gene | ZC4H2 |
| Organism | Homo sapiens |
| Length | 224 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (69)
Diseases linked to this target (Open Targets).
- Intellectual disability-developmental delay-contractures syndrome · score 0.81
- Wieacker-Wolff syndrome · score 0.79
- genetic disorder · score 0.52
- X-linked syndromic intellectual disability · score 0.37
- Neurodevelopmental disorder · score 0.27
- Wieacker-Wolff syndrome (spectrum) · score 0.12
- amyotrophic lateral sclerosis · score 0.07
- Mobius syndrome · score 0.07
- hereditary spastic paraplegia 25 · score 0.07
- Autosomal recessive spastic paraplegia type 25 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NQZ6-F1 | alphafold | PREDICTED | 83.22 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NQZ6.
Amino-acid sequence (224 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZC4H2?
The strongest Open Targets associations for ZC4H2 are Intellectual disability-developmental delay-contractures syndrome, Wieacker-Wolff syndrome, genetic disorder, X-linked syndromic intellectual disability and Neurodevelopmental disorder.
How long is the ZC4H2 protein?
The Homo sapiens ZC4H2 protein (UniProt Q9NQZ6) is 224 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NQZ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NQZ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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