Protein mono-ADP-ribosyltransferase PARP11 (PARP11)
Homo sapiens — UniProt Q9NR21
Data last refreshed: (UniProt release unknown)
Key facts
Protein mono-ADP-ribosyltransferase PARP11 (PARP11) is a protein from Homo sapiens identified by UniProt accession Q9NR21, 338 residues long. MolForge cross-references it against 0 known binders and 145 disease associations.
- UniProt accession: Q9NR21; gene symbol PARP11.
- Organism: Homo sapiens.
- Length: 338 amino acids.
- Top disease associations (Open Targets): mean corpuscular volume, mean corpuscular hemoglobin concentration and mean corpuscular hemoglobin.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein mono-ADP-ribosyltransferase PARP11 |
|---|---|
| UniProt accession | Q9NR21 |
| Gene | PARP11 |
| Organism | Homo sapiens |
| Length | 338 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (145)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.47
- mean corpuscular hemoglobin concentration · score 0.45
- mean corpuscular hemoglobin · score 0.44
- brain volume measurement · score 0.42
- neuroimaging measurement · score 0.40
- eosinophil count · score 0.40
- erythrocyte count · score 0.38
- platelet crit · score 0.35
- brain measurement · score 0.35
- mean reticulocyte volume · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NR21-F1 | alphafold | PREDICTED | 81.47 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NR21.
Amino-acid sequence (338 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PARP11?
The strongest Open Targets associations for PARP11 are mean corpuscular volume, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, brain volume measurement and neuroimaging measurement.
How long is the PARP11 protein?
The Homo sapiens PARP11 protein (UniProt Q9NR21) is 338 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NR21 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NR21 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.