Protein arginine N-methyltransferase 8 (PRMT8)
Homo sapiens — UniProt Q9NR22
Data last refreshed: (UniProt release unknown)
Key facts
Protein arginine N-methyltransferase 8 (PRMT8) is a protein from Homo sapiens identified by UniProt accession Q9NR22, 394 residues long. MolForge cross-references it against 0 known binders and 156 disease associations.
- UniProt accession: Q9NR22; gene symbol PRMT8.
- Organism: Homo sapiens.
- Length: 394 amino acids.
- Top disease associations (Open Targets): gut microbiome measurement, genetic disorder and glomerular filtration rate.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein arginine N-methyltransferase 8 |
|---|---|
| UniProt accession | Q9NR22 |
| Gene | PRMT8 |
| Organism | Homo sapiens |
| Length | 394 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (156)
Diseases linked to this target (Open Targets).
- gut microbiome measurement · score 0.33
- genetic disorder · score 0.26
- glomerular filtration rate · score 0.15
- lean body mass · score 0.12
- creatinine measurement · score 0.12
- vital capacity · score 0.12
- appendicular lean mass · score 0.12
- neutrophil count · score 0.11
- body height · score 0.11
- platelet component distribution width · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NR22-F1 | alphafold | PREDICTED | 86.04 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NR22.
Amino-acid sequence (394 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PRMT8?
The strongest Open Targets associations for PRMT8 are gut microbiome measurement, genetic disorder, glomerular filtration rate, lean body mass and creatinine measurement.
How long is the PRMT8 protein?
The Homo sapiens PRMT8 protein (UniProt Q9NR22) is 394 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NR22 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NR22 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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