Growth/differentiation factor 3 (GDF3)
Homo sapiens — UniProt Q9NR23
Data last refreshed: (UniProt release unknown)
Key facts
Growth/differentiation factor 3 (GDF3) is a protein from Homo sapiens identified by UniProt accession Q9NR23, 364 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.
- UniProt accession: Q9NR23; gene symbol GDF3.
- Organism: Homo sapiens.
- Length: 364 amino acids.
- Top disease associations (Open Targets): isolated microphthalmia 7, microphthalmia, isolated, with coloboma and Klippel-Feil syndrome 3, autosomal dominant.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Growth/differentiation factor 3 |
|---|---|
| UniProt accession | Q9NR23 |
| Gene | GDF3 |
| Organism | Homo sapiens |
| Length | 364 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (64)
Diseases linked to this target (Open Targets).
- isolated microphthalmia 7 · score 0.59
- microphthalmia, isolated, with coloboma · score 0.54
- Klippel-Feil syndrome 3, autosomal dominant · score 0.53
- Isolated anophthalmia - microphthalmia · score 0.46
- isolated Klippel-Feil syndrome · score 0.37
- neurodegenerative disease · score 0.19
- microphthalmia · score 0.19
- apolipoprotein A 1 measurement · score 0.09
- neoplasm · score 0.07
- Sepsis · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NR23-F1 | alphafold | PREDICTED | 82.52 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NR23.
Amino-acid sequence (364 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GDF3?
The strongest Open Targets associations for GDF3 are isolated microphthalmia 7, microphthalmia, isolated, with coloboma, Klippel-Feil syndrome 3, autosomal dominant, Isolated anophthalmia - microphthalmia and isolated Klippel-Feil syndrome.
How long is the GDF3 protein?
The Homo sapiens GDF3 protein (UniProt Q9NR23) is 364 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NR23 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NR23 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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