Small COPII coat GTPase SAR1A (SAR1A)
Homo sapiens — UniProt Q9NR31
Data last refreshed: (UniProt release unknown)
Key facts
Small COPII coat GTPase SAR1A (SAR1A) is a protein from Homo sapiens identified by UniProt accession Q9NR31, 198 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.
- UniProt accession: Q9NR31; gene symbol SAR1A.
- Organism: Homo sapiens.
- Length: 198 amino acids.
- Top disease associations (Open Targets): PHF-tau measurement, renal cell carcinoma and chylomicron retention disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Small COPII coat GTPase SAR1A |
|---|---|
| UniProt accession | Q9NR31 |
| Gene | SAR1A |
| Organism | Homo sapiens |
| Length | 198 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (37)
Diseases linked to this target (Open Targets).
- PHF-tau measurement · score 0.08
- renal cell carcinoma · score 0.07
- chylomicron retention disease · score 0.04
- neoplasm · score 0.03
- erythrocyte count · score 0.03
- aspartate aminotransferase measurement · score 0.03
- inorganic pyrophosphatase measurement · score 0.02
- squamous cell carcinoma · score 0.02
- sickle cell anemia · score 0.01
- nonpapillary renal cell carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NR31-F1 | alphafold | PREDICTED | 85.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NR31.
Amino-acid sequence (198 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SAR1A?
The strongest Open Targets associations for SAR1A are PHF-tau measurement, renal cell carcinoma, chylomicron retention disease, neoplasm and erythrocyte count.
How long is the SAR1A protein?
The Homo sapiens SAR1A protein (UniProt Q9NR31) is 198 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NR31 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NR31 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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