Endophilin-B2 (SH3GLB2)

About Endophilin-B2

Endophilin-B2 (SH3GLB2) is a protein from Homo sapiens identified by UniProt accession Q9NR46, 395 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.

Target properties

Protein name	Endophilin-B2
UniProt accession	Q9NR46
Gene	SH3GLB2
Organism	Homo sapiens
Length	395 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (36)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.29
Parkinson disease · score 0.29
multiple sclerosis · score 0.29
Alzheimer disease · score 0.29
lysosomal storage disease · score 0.29
blood metabolite measurement · score 0.04
neoplasm · score 0.04
Red cell distribution width · score 0.04
protein measurement · score 0.03
grip strength measurement · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NR46-F1	alphafold	PREDICTED	78.32	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NR46.

Amino-acid sequence (395 residues)

MDFNMKKLAS DAGIFFTRAV QFTEEKFGQA EKTELDAHFE NLLARADSTK NWTEKILRQT EVLLQPNPSA RVEEFLYEKL DRKVPSRVTN GELLAQYMAD AASELGPTTP YGKTLIKVAE AEKQLGAAER DFIHTASISF LTPLRNFLEG DWKTISKERR LLQNRRLDLD ACKARLKKAK AAEAKATTVP DFQETRPRNY ILSASASALW NDEVDKAEQE LRVAQTEFDR QAEVTRLLLE GISSTHVNHL RCLHEFVKSQ TTYYAQCYRH MLDLQKQLGR FPGTFVGTTE PASPPLSSTS PTTAAATMPV VPSVASLAPP GEASLCLEEV APPASGTRKA RVLYDYEAAD SSELALLADE LITVYSLPGM DPDWLIGERG NKKGKVPVTY LELLS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards