Endophilin-B2 (SH3GLB2)
Homo sapiens — UniProt Q9NR46
Data last refreshed: (UniProt release unknown)
Key facts
Endophilin-B2 (SH3GLB2) is a protein from Homo sapiens identified by UniProt accession Q9NR46, 395 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.
- UniProt accession: Q9NR46; gene symbol SH3GLB2.
- Organism: Homo sapiens.
- Length: 395 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Parkinson disease and multiple sclerosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Endophilin-B2 |
|---|---|
| UniProt accession | Q9NR46 |
| Gene | SH3GLB2 |
| Organism | Homo sapiens |
| Length | 395 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.29
- Parkinson disease · score 0.29
- multiple sclerosis · score 0.29
- Alzheimer disease · score 0.29
- lysosomal storage disease · score 0.29
- blood metabolite measurement · score 0.04
- neoplasm · score 0.04
- Red cell distribution width · score 0.04
- protein measurement · score 0.03
- grip strength measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NR46-F1 | alphafold | PREDICTED | 78.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NR46.
Amino-acid sequence (395 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SH3GLB2?
The strongest Open Targets associations for SH3GLB2 are neurodegenerative disease, Parkinson disease, multiple sclerosis, Alzheimer disease and lysosomal storage disease.
How long is the SH3GLB2 protein?
The Homo sapiens SH3GLB2 protein (UniProt Q9NR46) is 395 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NR46 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NR46 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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