Translation initiation factor eIF2B subunit gamma (EIF2B3)
Homo sapiens — UniProt Q9NR50
Data last refreshed: (UniProt release unknown)
Key facts
Translation initiation factor eIF2B subunit gamma (EIF2B3) is a protein from Homo sapiens identified by UniProt accession Q9NR50, 452 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.
- UniProt accession: Q9NR50; gene symbol EIF2B3.
- Organism: Homo sapiens.
- Length: 452 amino acids.
- Top disease associations (Open Targets): CACH syndrome, leukoencephalopathy with vanishing white matter and leukoencephalopathy with vanishing white matter 1.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Translation initiation factor eIF2B subunit gamma |
|---|---|
| UniProt accession | Q9NR50 |
| Gene | EIF2B3 |
| Organism | Homo sapiens |
| Length | 452 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (61)
Diseases linked to this target (Open Targets).
- CACH syndrome · score 0.62
- leukoencephalopathy with vanishing white matter · score 0.56
- leukoencephalopathy with vanishing white matter 1 · score 0.44
- ovarioleukodystrophy · score 0.37
- late infantile CACH syndrome · score 0.37
- congenital or early infantile CACH syndrome · score 0.37
- juvenile or adult CACH syndrome · score 0.37
- genetic disorder · score 0.19
- platelet component distribution width · score 0.11
- Blackfan-Diamond anemia · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NR50-F1 | alphafold | PREDICTED | 72.53 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NR50.
Amino-acid sequence (452 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EIF2B3?
The strongest Open Targets associations for EIF2B3 are CACH syndrome, leukoencephalopathy with vanishing white matter, leukoencephalopathy with vanishing white matter 1, ovarioleukodystrophy and late infantile CACH syndrome.
How long is the EIF2B3 protein?
The Homo sapiens EIF2B3 protein (UniProt Q9NR50) is 452 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NR50 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NR50 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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