Delta-like protein 4 (DLL4)
Homo sapiens — UniProt Q9NR61
Data last refreshed: (UniProt release unknown)
Key facts
Delta-like protein 4 (DLL4) is a protein from Homo sapiens identified by UniProt accession Q9NR61, 685 residues long. MolForge cross-references it against 0 known binders and 294 disease associations.
- UniProt accession: Q9NR61; gene symbol DLL4.
- Organism: Homo sapiens.
- Length: 685 amino acids.
- Top disease associations (Open Targets): Adams-Oliver syndrome, cancer and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Delta-like protein 4 |
|---|---|
| UniProt accession | Q9NR61 |
| Gene | DLL4 |
| Organism | Homo sapiens |
| Length | 685 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (294)
Diseases linked to this target (Open Targets).
- Adams-Oliver syndrome · score 0.76
- cancer · score 0.57
- neurodegenerative disease · score 0.37
- aplasia cutis congenita · score 0.37
- genetic disorder · score 0.34
- cognitive function measurement · score 0.31
- intelligence · score 0.30
- head and neck squamous cell carcinoma · score 0.29
- verbal-numerical reasoning measurement · score 0.24
- self reported educational attainment · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NR61-F1 | alphafold | PREDICTED | 74.85 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NR61.
Amino-acid sequence (685 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DLL4?
The strongest Open Targets associations for DLL4 are Adams-Oliver syndrome, cancer, neurodegenerative disease, aplasia cutis congenita and genetic disorder.
How long is the DLL4 protein?
The Homo sapiens DLL4 protein (UniProt Q9NR61) is 685 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NR61 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NR61 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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