Kelch-like protein 1 (KLHL1)
Homo sapiens — UniProt Q9NR64
Data last refreshed: (UniProt release unknown)
Key facts
Kelch-like protein 1 (KLHL1) is a protein from Homo sapiens identified by UniProt accession Q9NR64, 748 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.
- UniProt accession: Q9NR64; gene symbol KLHL1.
- Organism: Homo sapiens.
- Length: 748 amino acids.
- Top disease associations (Open Targets): tonsillectomy risk measurement, peritonsillar abscess and childhood onset asthma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Kelch-like protein 1 |
|---|---|
| UniProt accession | Q9NR64 |
| Gene | KLHL1 |
| Organism | Homo sapiens |
| Length | 748 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (39)
Diseases linked to this target (Open Targets).
- tonsillectomy risk measurement · score 0.42
- peritonsillar abscess · score 0.34
- childhood onset asthma · score 0.33
- age at onset · score 0.33
- environmental tobacco smoke exposure measurement · score 0.33
- stenosing tenosynovitis · score 0.32
- upper respiratory tract disorder · score 0.31
- neurofibrillary tangles measurement · score 0.24
- protein measurement · score 0.21
- chronotype measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NR64-F1 | alphafold | PREDICTED | 78.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NR64.
Amino-acid sequence (748 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KLHL1?
The strongest Open Targets associations for KLHL1 are tonsillectomy risk measurement, peritonsillar abscess, childhood onset asthma, age at onset and environmental tobacco smoke exposure measurement.
How long is the KLHL1 protein?
The Homo sapiens KLHL1 protein (UniProt Q9NR64) is 748 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NR64 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NR64 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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