Rho guanine nucleotide exchange factor 4 (ARHGEF4)
Homo sapiens — UniProt Q9NR80
Data last refreshed: (UniProt release unknown)
Key facts
Rho guanine nucleotide exchange factor 4 (ARHGEF4) is a protein from Homo sapiens identified by UniProt accession Q9NR80, 690 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.
- UniProt accession: Q9NR80; gene symbol ARHGEF4.
- Organism: Homo sapiens.
- Length: 690 amino acids.
- Top disease associations (Open Targets): PHF-tau measurement, neurofibrillary tangles measurement and thyroid gland adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rho guanine nucleotide exchange factor 4 |
|---|---|
| UniProt accession | Q9NR80 |
| Gene | ARHGEF4 |
| Organism | Homo sapiens |
| Length | 690 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (38)
Diseases linked to this target (Open Targets).
- PHF-tau measurement · score 0.28
- neurofibrillary tangles measurement · score 0.28
- thyroid gland adenocarcinoma · score 0.22
- congenital left-sided heart lesions · score 0.18
- breast adenocarcinoma · score 0.18
- neuroblastoma · score 0.11
- neoplasm · score 0.04
- colorectal neoplasm · score 0.03
- sitosterolemia · score 0.03
- atypical teratoid rhabdoid tumor · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NR80-F1 | alphafold | PREDICTED | 69.40 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NR80.
Amino-acid sequence (690 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARHGEF4?
The strongest Open Targets associations for ARHGEF4 are PHF-tau measurement, neurofibrillary tangles measurement, thyroid gland adenocarcinoma, congenital left-sided heart lesions and breast adenocarcinoma.
How long is the ARHGEF4 protein?
The Homo sapiens ARHGEF4 protein (UniProt Q9NR80) is 690 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NR80 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NR80 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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