Rho guanine nucleotide exchange factor 3 (ARHGEF3)
Homo sapiens — UniProt Q9NR81
Data last refreshed: (UniProt release unknown)
Key facts
Rho guanine nucleotide exchange factor 3 (ARHGEF3) is a protein from Homo sapiens identified by UniProt accession Q9NR81, 526 residues long. MolForge cross-references it against 0 known binders and 121 disease associations.
- UniProt accession: Q9NR81; gene symbol ARHGEF3.
- Organism: Homo sapiens.
- Length: 526 amino acids.
- Top disease associations (Open Targets): platelet count, mean platelet volume and platelet crit.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rho guanine nucleotide exchange factor 3 |
|---|---|
| UniProt accession | Q9NR81 |
| Gene | ARHGEF3 |
| Organism | Homo sapiens |
| Length | 526 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (121)
Diseases linked to this target (Open Targets).
- platelet count · score 0.40
- mean platelet volume · score 0.39
- platelet crit · score 0.36
- platelet component distribution width · score 0.30
- blood protein measurement · score 0.28
- adolescent idiopathic scoliosis · score 0.28
- lymphocyte count · score 0.27
- reticulocyte count · score 0.26
- calcium measurement · score 0.24
- reticulocyte measurement · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NR81-F1 | alphafold | PREDICTED | 73.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NR81.
Amino-acid sequence (526 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARHGEF3?
The strongest Open Targets associations for ARHGEF3 are platelet count, mean platelet volume, platelet crit, platelet component distribution width and blood protein measurement.
How long is the ARHGEF3 protein?
The Homo sapiens ARHGEF3 protein (UniProt Q9NR81) is 526 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NR81 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NR81 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.