Deleted in azoospermia protein 3 (DAZ3)
Homo sapiens — UniProt Q9NR90
Data last refreshed: (UniProt release unknown)
Key facts
Deleted in azoospermia protein 3 (DAZ3) is a protein from Homo sapiens identified by UniProt accession Q9NR90, 486 residues long. MolForge cross-references it against 0 known binders and 134 disease associations.
- UniProt accession: Q9NR90; gene symbol DAZ3.
- Organism: Homo sapiens.
- Length: 486 amino acids.
- Top disease associations (Open Targets): azoospermia, male infertility with teratozoospermia due to single gene mutation and partial chromosome Y deletion.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Deleted in azoospermia protein 3 |
|---|---|
| UniProt accession | Q9NR90 |
| Gene | DAZ3 |
| Organism | Homo sapiens |
| Length | 486 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (134)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- partial chromosome Y deletion · score 0.08
- spermatogenic failure 1 · score 0.08
- spermatogenic failure 48 · score 0.07
- primary ovarian insufficiency · score 0.07
- spermatogenic failure 25 · score 0.07
- spermatogenic failure 22 · score 0.07
- spermatogenic failures 50 · score 0.07
- spermatogenic failure, X-linked, 3 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NR90-F1 | alphafold | PREDICTED | 62.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NR90.
Amino-acid sequence (486 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DAZ3?
The strongest Open Targets associations for DAZ3 are azoospermia, male infertility with teratozoospermia due to single gene mutation, partial chromosome Y deletion, spermatogenic failure 1 and spermatogenic failure 48.
How long is the DAZ3 protein?
The Homo sapiens DAZ3 protein (UniProt Q9NR90) is 486 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NR90 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NR90 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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