Sphingosine kinase 2 (SPHK2)
Homo sapiens — UniProt Q9NRA0
Data last refreshed: (UniProt release unknown)
Key facts
Sphingosine kinase 2 (SPHK2) is a protein from Homo sapiens identified by UniProt accession Q9NRA0, 654 residues long. MolForge cross-references it against 0 known binders and 252 disease associations.
- UniProt accession: Q9NRA0; gene symbol SPHK2.
- Organism: Homo sapiens.
- Length: 654 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lymphocyte count and reticulocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sphingosine kinase 2 |
|---|---|
| UniProt accession | Q9NRA0 |
| Gene | SPHK2 |
| Organism | Homo sapiens |
| Length | 654 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (252)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- lymphocyte count · score 0.24
- reticulocyte count · score 0.24
- Red cell distribution width · score 0.23
- reticulocyte measurement · score 0.23
- neutrophil percentage of leukocytes · score 0.23
- lymphocyte percentage of leukocytes · score 0.23
- Immature Reticulocyte Fraction Measurement · score 0.20
- mean reticulocyte volume · score 0.17
- neutrophil count · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NRA0-F1 | alphafold | PREDICTED | 76.83 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRA0.
Amino-acid sequence (654 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPHK2?
The strongest Open Targets associations for SPHK2 are neurodegenerative disease, lymphocyte count, reticulocyte count, Red cell distribution width and reticulocyte measurement.
How long is the SPHK2 protein?
The Homo sapiens SPHK2 protein (UniProt Q9NRA0) is 654 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NRA0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NRA0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.