F-box only protein 8 (FBXO8)
Homo sapiens — UniProt Q9NRD0
Data last refreshed: (UniProt release unknown)
Key facts
F-box only protein 8 (FBXO8) is a protein from Homo sapiens identified by UniProt accession Q9NRD0, 319 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.
- UniProt accession: Q9NRD0; gene symbol FBXO8.
- Organism: Homo sapiens.
- Length: 319 amino acids.
- Top disease associations (Open Targets): bilirubin measurement, heel bone mineral density and lower face morphology measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | F-box only protein 8 |
|---|---|
| UniProt accession | Q9NRD0 |
| Gene | FBXO8 |
| Organism | Homo sapiens |
| Length | 319 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (44)
Diseases linked to this target (Open Targets).
- bilirubin measurement · score 0.34
- heel bone mineral density · score 0.28
- lower face morphology measurement · score 0.23
- chin morphology measurement · score 0.23
- neurodegenerative disease · score 0.20
- electrocardiography · score 0.14
- abortion · score 0.11
- neoplasm · score 0.08
- colorectal carcinoma · score 0.08
- hepatocellular carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NRD0-F1 | alphafold | PREDICTED | 81.33 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRD0.
Amino-acid sequence (319 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FBXO8?
The strongest Open Targets associations for FBXO8 are bilirubin measurement, heel bone mineral density, lower face morphology measurement, chin morphology measurement and neurodegenerative disease.
How long is the FBXO8 protein?
The Homo sapiens FBXO8 protein (UniProt Q9NRD0) is 319 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NRD0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NRD0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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